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Cardiovascular Research

PGR-RA-40

Expertise of research area
aging; Cardiac arrhythmia; Cardiac remodelling and repair; skeletal muscle; Sport and Exercise Science; cardiovascular


Coronavirus information for applicants and offer holders

We hope that by the time you’re ready to start your studies with us the situation with COVID-19 will have eased. However, please be aware, we will continue to review our courses and other elements of the student experience in response to COVID-19 and we may need to adapt our provision to ensure students remain safe. For the most up-to-date information on COVID-19, regularly visit our website, which we will continue to update as the situation changes www.leeds.ac.uk/covid19faqs

<h2 class="heading hide-accessible">Summary</h2>

As part of the Cardiovascular and Sport and Exercise Sciences group, we were ranked 1st in the UK for world leading 4* research in the 2014 Research Excellence Framework (REF).

<h2 class="heading hide-accessible">Full description</h2>

<p>Our research, delivered under six&nbsp;themes, focuses on the function of the heart in health and disease, with additional activity in the area of skeletal muscle. From the level of the single molecule through to the function of the intact heart&nbsp;<em>in vivo</em>, complemented by multi-scale<em>&nbsp;in silico</em>&nbsp;modelling, we deliver world-class research with translational relevance.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/1">Molecular machinery of muscle contraction</a></h3> <p>Contraction of cardiac and skeletal muscle depends on the precise arrangement and interaction of elements of the excitation-contraction machinery and of the signalling pathways that regulate these.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/2">Cardiac arrhythmia</a></h3> <p>Cardiac arrhythmias occur when the heart&rsquo;s electrical activity becomes chaotic and it can no longer pump blood efficiently. Ageing, certain conditions such as heart failure, and even intense exercise training can increase the risk of arrhythmias.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/3">Cardiac remodelling and repair</a></h3> <p>Cardiac adaptions through remodelling and repair occur at multiple levels and throughout life. One highly-contested area of research is the extent of myocardial regeneration that takes place following myocardial damage, and the role of stem or progenitor cells in this.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/4">Skeletal muscle in health and disease</a></h3> <p>Skeletal muscle is vital for life, underpinning locomotion, respiration, and metabolism, yet we still poorly understand its response to exercise and disease.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/5">Ageing and the cardiopulmonary system</a></h3> <p>Age is a major risk factor for the majority of cardiopulmonary complications. In part this is because many cardiovascular and pulmonary diseases are progressive. However, even healthy ageing is associated with a reduction in blood vessel and lung function, with a sharp decline in maximal cardiac output and aerobic capacity as people advance into their 60s and beyond.</p> <h3><a href="https://biologicalsciences.leeds.ac.uk/cardiovascular/doc/cardiovascular-research-themes/page/6">Exercise and the failing heart</a></h3> <p>Heart failure is a complex syndrome with impairment of cardiac, respiratory, musculoskeletal and vascular function, all of which contribute to reduced quality of life and mortality. Exercise has established benefits in patients with heart failure but debate continues as to the most appropriate exercise modality.</p>

<h2 class="heading">How to apply</h2>

<p>If you are interested in a&nbsp;product in this research area please search for our <a href="https://biologicalsciences.leeds.ac.uk/research-degrees/doc/how-to-apply">research opportunities</a>.&nbsp;</p>

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Graduate School Office<br /> e: <a href="mailto:https://biologicalsciences.leeds.ac.uk/research-degrees">fbsgrads</a><a href="mailto:EMAIL@leeds.ac.uk">@leeds.ac.uk</a>, t: +44 (0)113 343 8186</p>


<h2 class="heading heading--sm">Linked project opportunities</h2>
<h2 class="heading heading--sm">Linked funding opportunities</h2>