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Myocardial perfusion, interstitial fibrosis and cardiomyocyte volume in the development of cardiac hypertrophy measured with contrast-enhanced MRI.

PGR-P-175

Key facts

Type of research degree
4 year PhD
Application deadline
Ongoing deadline
Country eligibility
International (outside UK)
Funding
Non-funded
Supervisors
Professor David Buckley and Professor Sven Plein
Additional supervisors
John Biglands
Schools
School of Medicine
Research groups/institutes
Leeds Institute of Cardiovascular and Metabolic Medicine
<h2 class="heading hide-accessible">Summary</h2>

Recent pre-clinical studies have indicated that in addition to measures of myocardial perfusion and interstitial fibrosis, contrast-enhanced MRI may be sensitive to changes in cardiomyocyte volume due to limitations in the rate of water exchange across the cell wall [1]. This is a potentially useful measure of early cardiac hypertrophy but the sensitivity and precision of such measurements has not yet been established.

<h2 class="heading hide-accessible">Full description</h2>

<h3>Methods:</h3> <p>Simulation studies will be undertaken to determine the sensitivity of dynamic contrast-enhanced MRI to changes in cardiomyocyte volume. The effect of multiple contrast agent injections and changes in the way in which the MRI data are acquired will be assessed. Once an optimized imaging protocol is designed, MRI studies will be performed in volunteers and subsequently in patients before and after transcatheter aortic valve implantation (TAVI). Estimates of myocardial perfusion, cardiomyocyte and interstitial volume will be obtained from those data.</p> <h3>Outcomes:</h3> <p>The project will produce recommendations for optimized MR imaging protocols to measure cardiomyocyte volume and assess the effect of TAVI on the parameters measured.</p> <h3>References:</h3> <p>Coelho-Filho OR, Mongeon FP, Mitchell R, Moreno H, Jr., Nadruz W, Jr., Kwong R, et al. Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease. Circulation: Cardiovasc Imaging. 2013;6(1):134-41.</p>

<h2 class="heading">How to apply</h2>

<p>Please note these are not standalone projects and applicants must apply to the PhD academy directly.</p> <p>Applications can be made at any time. To apply for this project applicants should complete a<a href="https://medicinehealth.leeds.ac.uk/downloads/download/129/faculty_graduate_school_-_application_form"> Faculty Application Form</a> and send this alongside a full academic CV, degree transcripts (or marks so far if still studying) and degree certificates to the Faculty Graduate School <a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a></p> <p>We also require 2 academic references to support your application. Please ask your referees to send these <a href="https://medicinehealth.leeds.ac.uk/downloads/download/130/faculty_graduate_school_-_scholarship_reference_form">references</a> on your behalf, directly to <a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a></p> <p>If you have already applied for other projects using the Faculty Application Form this academic session you do not need to complete this form again. Instead you should email fmhgrad to inform us you would like to be considered for this project.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p>

<h2 class="heading heading--sm">Entry requirements</h2>

A degree in physics, maths, engineering or computer science or a good honours degree in a subject relevant to the research topic. A Masters degree in a relevant subject may also be required in some areas of the Faculty. For entry requirements for all other research degrees we offer, please contact us.

<h2 class="heading heading--sm">English language requirements</h2>

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The Faculty of Medicine and Health minimum requirements in IELTS and TOEFL tests for PhD, MSc, MPhil, MD are: &acirc;&euro;&cent; British Council IELTS - score of 7.0 overall, with no element less than 6.5 &acirc;&euro;&cent; TOEFL iBT - overall score of 100 with the listening and reading element no less than 22, writing element no less than 23 and the speaking element no less than 24.

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Graduate School Office<br /> e:<a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a>, t: +44 (0)113 343 8221.</p>


<h3 class="heading heading--sm">Linked research areas</h3>