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The role of matricellular proteins in notch signalling and cell survival after myocardial infarction

PGR-P-686

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Key facts

Type of research degree
4 year PhD
Application deadline
Ongoing deadline
Country eligibility
International (outside UK)
Funding
Non-funded
Supervisors
Dr Azhar Maqbool and Dr Neil Turner
Additional supervisors
Mark Drinkhill
Schools
School of Medicine
Research groups/institutes
Leeds Institute of Cardiovascular and Metabolic Medicine
<h2 class="heading hide-accessible">Summary</h2>

Studies using genetic ablation or activation of Notch signalling have demonstrated that Notch signalling, plays a critical role in cardiac repair and regeneration after myocardial injury. The activation of Notch signalling suppresses cardiomyocytes apoptosis, minimizes fibrosis, increases neovascularization and improves cardiac function and outcome after myocardial infarction (MI). Hence, modulation of Notch signalling may serve as a tool to limit ventricular remodelling and dysfunction after injury. The matricellular protein, tenascin C (TNC) is upregulated following cardiac injury where it plays a role in tissue remodelling. TNC can activate Notch signalling in tumour tissue promoting both survival and growth, however, its role in Notch-mediated cardio-protection in the injured heart remains unexplored. This study aims to investigate the effect of TNC on Notch mediated protective signalling in the heart following injury. Studies will be conducted on isolated cardiac fibroblasts and myoctes as well as mouse models of myocardial injury.

<h2 class="heading hide-accessible">Full description</h2>

<h6>References</h6> <ol> <li>Natalie Gude, and Mark Sussman. Notch signaling and cardiac repair. J Mol Cell Cardiol. 2012 Jun; 52(6): 1226&ndash;1232.</li> <li>Yuxin Li, Yukio Hiroi and James K. Liao. Notch Signaling as an Important Mediator of Cardiac Repair and Regeneration after Myocardial Infarction. Trends Cardiovasc Med. 2010 Oct; 20(7): 228&ndash;231.</li> <li>Imanaka-Yoshida K. Tenascin-C in cardiovascular tissue remodeling: from development to inflammation and repair. Circ J. 2012; 76(11):2513-20.&nbsp;<br /> &nbsp;</li> </ol>

<h2 class="heading">How to apply</h2>

<p>Please note these are not standalone projects and applicants must apply to the PhD academy directly.</p> <p>Applications can be made at any time. You should complete an <a href="https://medicinehealth.leeds.ac.uk/faculty-graduate-school/doc/apply-2">online application form</a> and attach the following documentation to support your application.&nbsp;</p> <ul> <li>a full academic CV</li> <li>degree certificate and transcripts of marks (or marks so far if still studying)</li> <li>Evidence that you meet the programme&rsquo;s minimum English language requirements (if applicable, see requirement below)</li> <li>Evidence of funding to support your studies</li> </ul> <p>To help us identify that you are applying for this project please ensure you provide the following information on your application form;</p> <ul> <li>Select PhD in Cardiovascular and Metabolic Disease as your programme of study</li> <li>Give the full project title and name the supervisors listed in this advert</li> </ul>

<h2 class="heading heading--sm">Entry requirements</h2>

A degree in biological sciences, dentistry, medicine, midwifery, nursing, psychology or a good honours degree in a subject relevant to the research topic. A Masters degree in a relevant subject may also be required in some areas of the Faculty. For entry requirements for all other research degrees we offer, please contact us.

<h2 class="heading heading--sm">English language requirements</h2>

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The minimum requirements for this programme in IELTS and TOEFL tests are: &bull; British Council IELTS - score of 7.0 overall, with no element less than 6.5 &bull; TOEFL iBT - overall score of 100 with the listening and reading element no less than 22, writing element no less than 23 and the speaking element no less than 24.

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Faculty Graduate School<br /> e:&nbsp;<a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a></p>


<h3 class="heading heading--sm">Linked research areas</h3>