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Blood biomarkers for differentiation of stroke from mimics using a novel laser optical technique

PGR-P-1709

Key facts

Type of research degree
4 year PhD
Application deadline
Ongoing deadline
Country eligibility
International (outside UK)
Funding
Non-funded
Supervisors
Professor Gin Jose and Professor Sikha Saha
Additional supervisors
Dr Ahamad Hassan
Schools
School of Medicine
Research groups/institutes
Leeds Institute of Cardiovascular and Metabolic Medicine
<h2 class="heading hide-accessible">Summary</h2>

Stroke is the second most common cause of mortality and the third most common cause of disability in the world. Despite advances in the field of neuroimaging, potential limitations such as lengthy procedure, costly equipment and image analysis variations have hampered their efficient use in acute stroke diagnosis and differentiation. A complimentary biomarker test to discriminate between stroke and stroke mimic will have the potential to be used for stroke management and treatment throughout the patient care pathways.

<h2 class="heading hide-accessible">Full description</h2>

<p>The proposed multidisciplinary project aims to use a novel laser technology developed in our lab to detect and quantify a range of brain damage biomarkers in blood plasma/ serum obtained from people with stroke, and stroke mimics. Clinical and radiological data will be used to define cases and controls and compare against biomarker levels. The specific objectives are,</p> <ul> <li>To conjugate antibodies against biomarkers with Up-conversion nanoparticles (UCNPs)&nbsp;</li> <li>To detect, quantify serum biomarkers with the functionalised UCNP and assess the specificity and sensitivity ((limit of detection) of the technique.</li> <li>To quantify brain specific circulating biomarkers between acute stroke and stroke-mimics using the technique&nbsp;</li> <li>To correlate biomarker concentrations with stroke severity and functional stroke outcome.</li> </ul> <h4>References</h4> <ul> <li>Bsat, et al., (2021), Acute ischemic stroke biomarkers: a new era with diagnostic promise? Acute Med Surg, 8: e696. <a href="https://doi.org/10.1002/ams2.696">https://doi.org/10.1002/ams2.696</a></li> <li>Bustamante et al., (2017) Blood Biomarkers for the Early Diagnosis of Stroke<br /> The Stroke-Chip Study, Stroke. 48:2419&ndash;2425</li> </ul>

<h2 class="heading">How to apply</h2>

<p>Please note these are not standalone projects and applicants must apply to the PhD academy directly.</p> <p>Applications can be made at any time. You should complete an&nbsp;<a href="https://medicinehealth.leeds.ac.uk/faculty-graduate-school/doc/apply-2">online application form</a>&nbsp;and attach the following documentation to support your application.&nbsp;</p> <ul> <li>a full academic CV</li> <li>degree certificate and transcripts of marks (or marks so far if still studying)</li> <li>Evidence that you meet the programme&rsquo;s minimum English language requirements (if applicable, see requirement below)</li> <li>Evidence of funding to support your studies</li> </ul> <p>To help us identify that you are applying for this project please ensure you provide the following information on your application form;</p> <ul> <li>Select PhD in Medicine, Health &amp; Human Disease&nbsp;as your programme of study</li> <li>Give the full project title and name the supervisors listed in this advert</li> </ul>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 7.0 overall with at least 6.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p>This project is for candidates who are able to self fund their studies.</p>

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Faculty Graduate School<br /> e:<a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a></p>


<h3 class="heading heading--sm">Linked research areas</h3>