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Targets and therapies

PGR-RA-145

Expertise of research area
cellular disease modelling; chemoprevention; nutrition; transcriptomics


<h2 class="heading hide-accessible">Summary</h2>

We identify diseases of unmet need and focus our research on the identification and validation of target molecules, which then inform the development of small molecule screens and new biologics for use in the clinic.

<h2 class="heading hide-accessible">Full description</h2>

<p>The programme to develop a new drug starts with a health condition with no suitable medicine, a disease of unmet need. Research aimed at drug discovery starts with the identifying the target, the nucleic acid, protein or signalling pathway that might be activated or inhibited to cause a therapeutic effect. Validation of this target increases confidence that this particular molecule is causative or involved in the disease mechanism. New therapies can then be found through screening for a small molecule or biologic that is effective against that target. Our research focuses on identification and validation of target molecules which then inform the development of small molecule screens and new biologics for use in the clinic.</p>

<h2 class="heading">How to apply</h2>

<p>To submit an application in this research area please complete an <a href="https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon">online application form</a> and submit this alongside a research proposal, a full academic CV, degree transcripts (or marks so far if still studying) and degree certificates. If English is not your first language, you must provide evidence that you meet the Faculty&rsquo;s minimum <a href="https://medicinehealth.leeds.ac.uk/faculty-graduate-school/doc/entry-requirements-1">English language requirements</a>.</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Graduate School Office<br /> e:&nbsp;<a href="mailto:fmhpgradmissions@leeds.ac.uk">fmhpgradmissions@leeds.ac.uk</a>, t: +44 (0)113 343 8221.</p>