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Library Synthesis in Flow Made Easier: DoE & ML

PGR-P-946

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Key facts

Type of research degree
PhD
Application deadline
Ongoing deadline
Project start date
Friday 1 October 2021
Country eligibility
UK only
Funding
Funded
Source of funding
Research council
Supervisors
Dr Richard Bourne
Additional supervisors
Natalie Fey - Bristol, David Burns & Claudio Battilocchio - Syngenta
Schools
School of Chemical and Process Engineering
<h2 class="heading hide-accessible">Summary</h2>

The opportunity for this project is to create a paradigm shift by enabling responsive library synthesis using flow technologies by bridging discovery and development activities. This will be achieved by developing digital models to enable fast and responsive optimisation of chemical processes combined with automated reactors which deliver global synthetic yield maxima for a given library set. Thereby achieving a higher success rate in library synthesis in a shorter space of time.<br />

<h2 class="heading hide-accessible">Full description</h2>

<p>The ability to optimise reactions conditions rapidly for possible synthetic challenge through high throughput experimentation (HTE) and automated screening cascades have long been industry standard workflows. Yet, many decisions made during the optimisation of a reaction towards a single compound (local&nbsp;synthetic yield maxima achieved) have unforeseen consequences when applied to the breadth of chemical diversity required from a given synthetic sequence when applied in a research project setting (global&nbsp;or multiple synthetic maxima required). Thus, synthetic sequences need to be re-designed from the beginning, which can lead to inefficient processes (time, cost, environmental burden etc.). Our accelerated approach aims to couple the learnings from the Bourne groups experience using algorithms for augmented experimental optimisation with early promising internal results by Syngenta. Our aim is to address this <em>l</em><em>ocal vs global</em>&nbsp;maxima problem for library synthesis in flow.</p>

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="http://www.leeds.ac.uk/rsa/prospective_students/apply/I_want_to_apply.html">University&#39;s website</a>. Please state clearly in the research information section&nbsp;that the research degree you wish to be considered for is&nbsp;<em><strong>Library Synthesis in Flow Made Easier: DoE &amp; ML</strong></em>&nbsp;as well as&nbsp;<a href="https://eps.leeds.ac.uk/faculty-engineering-physical-sciences/staff/596/dr-richard-bourne"><strong>Dr&nbsp;Richard Bourne</strong></a> as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p>A highly competitive EPSRC Industrial Case Studentship supported by Syngenta consisting of the award of fees with a maintenance grant of &pound;15,609&nbsp;for session 2021/22&nbsp;for 4 years with an additional stipend of &pound;3,000 per year.<br /> <br /> This opportunity is open to UK&nbsp;applicants only.&nbsp;All candidates will be placed into the EPSRC Industrial Case Studentship competition and selection is based on academic merit.<br /> <br /> The&nbsp;<a href="https://www.ukcisa.org.uk/">UKCISA</a>&nbsp;website will be updated in due course with information regarding Fee Status for Non-UK Nationals starting from September/October 2021.</p>

<h2 class="heading">Contact details</h2>

<p>For further information regarding the project, please contact Dr Richard Bourne<br /> e: <a href="mailto:r.a.bourne@leeds.ac.uk">r.a.bourne@leeds.ac.uk</a></p> <p>For further information regarding your application, please contact Doctoral College Admissions<br /> e:&nbsp;<a href="mailto:phd@engineering.leeds.ac.uk">phd@engineering.leeds.ac.uk</a></p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>
<h3 class="heading heading--sm">Linked research areas</h3>