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Developing novel nanostructures to modulate dendritic cell function for allergy treatment

PGR-P-795

Key facts

Type of research degree
PhD
Application deadline
Ongoing deadline
Country eligibility
International (open to all nationalities, including the UK)
Funding
Competition funded
Supervisors
Dr Yuan Guo
Schools
School of Chemistry, School of Food Science and Nutrition, School of Medicine
<h2 class="heading hide-accessible">Summary</h2>

Allergies (including food allergy) are caused by the abnormal hypersensitive immune responses to some harmless/beneficial substances (known as allergens). A class of immune cell, dendritic cells (DCs) play a central role in sensing self/harmless and foreign/harmful substances to generate appropriate immune instructions to maintain tolerance or activate immune defence. In this project, we will develop glycan-nanostructures to target DC surface receptors to stimulate DC tolerant signalling. By conjugating allergens onto these nanostructures, we aim to educate the abnormal function immune system to establish allergen specific immune tolerance to treat allergy.

<h2 class="heading hide-accessible">Full description</h2>

<p>The research is multidisciplinary across the School of Food Science and Nutrition, School of Chemistry, and School of Medicine, University of Leeds. &nbsp;Applicants must have (or expect to obtain) at least the equivalent of a UK upper second class Master&#39;s degree in chemistry, biophysics, or related area. Experience with chemical synthesis, nanotechnology would be advantageous. No experience in cell biology is necessary as training will be given. Applicants should have a keen interest in applying nanochemistry methods to biological systems and must enjoy working in a highly dynamic and collaborative environment.</p>

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="http://www.leeds.ac.uk/rsa/prospective_students/apply/I_want_to_apply.html">University&#39;s website</a>. Please state clearly in the research information section&nbsp;that the research degree you wish to be considered for is &ldquo;Developing novel nanostructures to modulate dendritic cell function for allergy treatment&rdquo; as well as&nbsp;<a href="https://environment.leeds.ac.uk/food-nutrition/staff/7394/dr-yuan-guo">Dr Yuan Guo</a> as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.5 overall with at least 6.0 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p><strong>Self-Funding Students</strong></p> <p><strong>Funding Eligibility &ndash; Please note that availability of these Scholarships will be announced in October 2020.</strong></p> <p><strong>UK/EU</strong>&nbsp;&ndash;&nbsp;Leeds Doctoral Scholarship Award paying Academic Fees and Maintenance matching EPSRC rate of &pound;15,285 per year for 3 years,</p> <p><strong>International Students</strong>&nbsp;&ndash;&nbsp;China Scholarship Council-University of Leeds Scholarship Award paying Academic Fees for 3 years,&nbsp; Commonwealth Scholarship.&nbsp;</p> <p><strong>Available</strong> &ndash; Alumni Bursary is available to previous University of Leeds graduates offering 10% discount on Academic Fees.</p>

<h2 class="heading">Contact details</h2>

<p>Any enquiries about the application procedure can be sent to&nbsp;<a href="mailto:maps.pgr.admissions@leeds.ac.uk">maps.pgr.admissions@leeds.ac.uk</a></p> <p>For further information regarding the project, please contact Dr Yuan Guo&nbsp;by email:&nbsp; <a href="mailto:y.guo@leeds.ac.uk">y.guo@leeds.ac.uk</a></p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>