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Understanding the origins of implant derived debris

PGR-P-778

Key facts

Type of research degree
PhD
Application deadline
Friday 19 June 2020
Project start date
Thursday 1 October 2020
Country eligibility
UK and EU
Funding
Funded
Source of funding
Doctoral training partnership
Supervisors
Dr Michael Bryant
Additional supervisors
Dr Andrew Beadling, Prof. Anne Neville, Prof. Richard Hall
Schools
School of Mechanical Engineering
Research groups/institutes
Institute of Functional Surfaces
<h2 class="heading hide-accessible">Summary</h2>

It has been proposed that taper corrosion in metal-on-polyethylene total hip arthroplasty (THA) has the potential to cause adverse local tissue reactions. This can go on to cause severe complications and ultimately failure of the implant through immune response. Several studies in the literature highlight that this is likely to be related to increased metal debris generated from the modular taper junction. ASTM and ISO standards are still primitive when it comes to assessing the complex degradation mechanisms of THA and often rely solely on simple gravimetric mass loss. Recent work at Leeds has pioneered in-situ measurement of these processes along with complex whole system THA simulation. Gauging performance is therefore difficult and no standard methodology exists to determine the size and properties of particles and/or metal ions and corrosion products released from aforementioned interfaces. External regulatory drivers from the FDA are now demanding manufacturers have a sound understanding of any potential source of debris or degradation products likely to arise from devices in vivo.&nbsp; This project therefore aims to characterise the size, morphology and chemical composition of wear debris and degradation products released from interfaces commonly found in THA components. For the first time state-of-the-art whole hip simulation will be used as opposed to studying the interfaces in isolation with the ability to systematically de-couple interfaces. This will increase the knowledge in the orthopaedic community about the size and properties of particles released specifically from taper junctions and how they compare to other articulating surfaces. Work will include in situ measurements of degradation as well as rigorous pre- and post-test analysis. Existing test methods and standards will be compared and used to inform novel testing methods and conditions.&nbsp; This exciting joint research activity will be done in collaboration with Zimmer-Biomet; one of the largest medical device innovation companies in the world. The proposed study and collaboration is timely given the recent changes in global regulatory approval and will yield a number of high impact peer review publications with international industrial co-authors.&nbsp;

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="https://www.leeds.ac.uk/info/130206/applying/91/applying_for_research_degrees">University&#39;s website</a>. Please state clearly in the research information section&nbsp;that the research degree you wish to be considered for is &lsquo;<strong><em>Understanding the origins of implant derived debris</em></strong>&rsquo; as well as <a href="https://eps.leeds.ac.uk/mechanical-engineering/staff/476/dr-michael-bryant"><em><strong>Dr Michael Bryant</strong></em></a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p>A highly competitive EPSRC Studentship Award offering Academic Fee at Home/EU Fee rate, plus Maintenance of &pound;15,285 per year for 3.5 years.&nbsp;Note to EU Candidates: To be eligible for the full award of fees and maintenance, you must be have residency in the UK for 3 or more years. If you do not have 3 years residency in the UK, you may be eligible for a Fee Only award. Please note that International applicants are not eligible to apply for this funding. Funding is awarded on a competitive basis.</p>

<h2 class="heading">Contact details</h2>

<p>For further information regarding your application,&nbsp;please contact Doctoral College Admissions:&nbsp; e:&nbsp;<a href="mailto:phd@engineering.leeds.ac.uk">phd@engineering.leeds.ac.uk</a></p> <p>For further information regarding the project, please contact Dr Michael Bryant:<br /> e:&nbsp;<a href="mailto:m.g.bryant@leeds.ac.uk">m.g.bryant@leeds.ac.uk</a> , t: +44 (0)113 343 2161.</p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>
<h3 class="heading heading--sm">Linked research areas</h3>