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Targeting TRPM2 ionic signalling to prevent neuronal cell death

PGR-P-636

Key facts

Type of research degree
PhD
Application deadline
Monday 1 June 2020
Project start date
Thursday 1 October 2020
Country eligibility
UK and EU
Funding
Non-funded
Source of funding
Other
Supervisors
Professor Rao Sivaprasadarao
Schools
School of Biomedical Sciences
Research groups/institutes
Neuroscience
<h2 class="heading hide-accessible">Summary</h2>

Neuronal cell death occurs in a number of disease states, including Alzheimer&rsquo;s, Parkinson&rsquo;s disease and Stroke.

<h2 class="heading hide-accessible">Full description</h2>

<p>&nbsp;Emerging evidence suggests that TRPM2 channels play a causative role in all of these diseases. Activation of TRPM2 channels leads to altered homeostasis of Ca<sup>2+</sup> and Zn<sup>2+</sup> and mitochondrial abnormalities (<a href="https://stke.sciencemag.org/content/sigtrans/10/490/eaal4161.full.pdf">https://stke.sciencemag.org/content/sigtrans/10/490/eaal4161.full.pdf</a>). &nbsp;The aim of this project is to develop novel biologics (antibodies and proteins) and chemicals against TRPM2 signalling and test their ability to prevent cell death using disease models. The results are expected to reveal novel treatment strategies for neurodegenerative diseases.</p>

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="http://www.leeds.ac.uk/rsa/prospective_students/apply/I_want_to_apply.html">University&#39;s website</a>. Please select PhD in Biological Sciences as your proposed course and state clearly in the research information section&nbsp;that the research degree to be considered for is &ldquo;Targeting TRPM2 ionic signalling to prevent neuronal cell death&rdquo; as well as&nbsp;<a href="https://biologicalsciences.leeds.ac.uk/school-biomedical-sciences/staff/135/professor-asipu-sivaprasadarao">Prof. Sivaprasadarao</a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p>We encourage candidates to apply for the&nbsp;<a href="https://phd.leeds.ac.uk/funding/44-emma-and-leslie-reid-research-scholarship-2020">Emma and Leslie Reid Research Scholarship 2020</a></p>

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Graduate School Office<br /> e:&nbsp;<a href="mailto:EMAIL@leeds.ac.uk">f</a><a href="mailto:fbsgrad@leeds.ac.uk">bsgrad@leeds.ac.uk</a>, t: +44 (0)113 343 8186</p> <p>or</p> <p><a href="mailto:a.sivaprasadarao@leeds.ac.uk">a.sivaprasadarao@leeds.ac.uk</a>&nbsp;(PhD supervisor)</p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>
<h3 class="heading heading--sm">Linked research areas</h3>