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Targeting TRPM2- Zin2+ signalling to prevent metastatic cancer

PGR-P-635

Key facts

Type of research degree
PhD
Application deadline
Monday 1 June 2020
Project start date
Thursday 1 October 2020
Country eligibility
UK and EU
Funding
Non-funded
Source of funding
University of Leeds
Supervisors
Professor Rao Sivaprasadarao
Schools
School of Biomedical Sciences
Research groups/institutes
Cancer
<h2 class="heading hide-accessible">Summary</h2>

Cancer can spread from its site of origin to other parts of the body - a process termed metastasis. Metastasis is the primary cause of cancer morbidity and mortality and accounts for about 90% of cancer deaths.

<h2 class="heading hide-accessible">Full description</h2>

<p>We have recently discovered that inhibition of TRPM2 ion channels and the TRPM2-mediated Zn<span class="superscript_text">2+</span> signalling prevents prostate cancer cell migration (<a href="https://jcs.biologists.org/content/joces/129/10/2016.full.pdf">https://jcs.biologists.org/content/joces/129/10/2016.full.pdf</a>). The aim of this project is to develop bespoke chemical compounds and biologics (proteins and antibodies) that specifically target TRPM2-Zn<span class="superscript_text">2+</span> signalling and test their ability to prevent cancer cell migration. The results are expected to reveal new therapeutic opportunities for cancer treatment.</p>

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="http://www.leeds.ac.uk/rsa/prospective_students/apply/I_want_to_apply.html">University&#39;s website</a>. Please select PhD in Biological Sciences as your proposed course and state clearly in the research information section&nbsp;that the research degree you wish to be considered for is &ldquo;Targeting TRPM2- Zin2+ signalling to prevent metastatic cancer&rdquo; as well as&nbsp;<a href="https://biologicalsciences.leeds.ac.uk/school-biomedical-sciences/staff/135/professor-asipu-sivaprasadarao">Prof. Sivaprasadarao</a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p>We encourage candidates to apply for the&nbsp;<a href="https://phd.leeds.ac.uk/funding/43-mary-and-alice-smith-memorial-scholarship-2020">Mary and Alice Smith Memorial Scholarship 2020</a></p>

<h2 class="heading">Contact details</h2>

<p>For further information please contact the Graduate School Office<br /> e:&nbsp;<a href="mailto:EMAIL@leeds.ac.uk">f</a><a href="mailto:fbsgrad@leeds.ac.uk">bsgrad@leeds.ac.uk</a>, t: +44 (0)113 343 8186</p> <p>or</p> <p><a href="mailto:a.sivaprasadarao@leeds.ac.uk">a.sivaprasadarao@leeds.ac.uk</a> (PhD supervisor)</p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>
<h3 class="heading heading--sm">Linked research areas</h3>