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How do dietary sterols alter cancer cell signalling originating from the plasma membrane?

PGR-P-263

Key facts

Type of research degree
PhD
Application deadline
Ongoing deadline
Country eligibility
International (open to all nationalities, including the UK)
Funding
Competition funded
Supervisors
Dr James Thorne
Schools
School of Food Science and Nutrition
<h2 class="heading hide-accessible">Summary</h2>

Cell membranes separate the cellular milieu from the external environment and regulate transport in and out of the cell. Membrane biology is a critical variable in chronic diseases associated with diet and nutrition due to the array of dietary factors that alter membrane composition and function.<br /> <br /> An emerging research focus is to determine how the array of exogenous dietary factors alter the cell membrane structure and function and how this impacts on chronic disease initiation and progression. A good example of this is how cancer hallmarks such as apoptosis evasion, increased proliferation and metabolic changes have their origins in (de)regulated membrane function. Therapeutic manipulation of the plasma membrane, either pharmacologically or through the diet is an underexploited research area for cancer prevention.<br /> <br /> This project will follow on from sucessfull on going research split across biophysics, cancer biology, structural biology and computational biology laboratories. he succssful candidate will develop skills in several areas - full training and support is provided.

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="https://www.leeds.ac.uk/info/130206/applying/91/applying_for_research_degrees">University&#39;s website</a>. Please state clearly in the research information section&nbsp;that the research degree you wish to be considered for is &lsquo;How do dietary sterols alter cancer cell signalling originating from the plasma membrane?&rsquo; as well as&nbsp;<a href="https://physicalsciences.leeds.ac.uk/staff/156/dr-james-l-thorne">Dr James Thorne</a> as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p><em>We welcome applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.</em></p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.5 overall with at least 6.0 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p><strong>Self-Funding Students are welcome to apply.</strong></p> <p><strong>UK&nbsp;students</strong>&nbsp;&ndash;&nbsp;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/138-leeds-doctoral-scholarships-2021-january-deadline">Leeds Doctoral Scholarship (January deadline)</a>&nbsp;is available to UK applicants. &nbsp;<a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Non-UK students</strong>&nbsp;&ndash;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/48-china-scholarship-council-university-of-leeds-scholarships-2021">China Scholarship Council - University of Leeds Scholarship</a>&nbsp;is available to nationals of China. The&nbsp;<a href="https://phd.leeds.ac.uk/funding/73-leeds-marshall-scholarship">Leeds Marshall Scholarship</a>&nbsp;is available to support US citizens. &nbsp;<a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p>

<h2 class="heading">Contact details</h2>

<p>For further information regarding your application,&nbsp; please contact Doctoral College Admissions by&nbsp;email:&nbsp;<a href="mailto:maps.pgr.admissions@leeds.ac.uk">maps.pgr.admissions@leeds.ac.uk</a>, or by&nbsp;telephone: +44 (0)113 343 5057.</p> <p>For further information regarding the project, please contact Dr James Thorne by email:&nbsp;&nbsp;<a href="mailto:J.L.Thorne@leeds.ac.uk">J.L.Thorne@leeds.ac.uk</a></p>


<h3 class="heading heading--sm">Linked research areas</h3>