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Novel Polymer Architectures for Controlled Release Applications

PGR-P-206

Key facts

Type of research degree
PhD
Application deadline
Ongoing deadline
Country eligibility
International (open to all nationalities, including the UK)
Funding
Competition funded
Supervisors
Dr Paul Thornton
Schools
School of Chemistry
<h2 class="heading hide-accessible">Summary</h2>

Polymers are frequently utilised as carrier vehicles for the controlled release of a molecular cargo in response to programmed stimulation. The use of stimuli-responsive polymers in this manner enables the release of therapeutic molecules, perfume molecules and dye molecules, amongst others, on-demand, and so has wide-reaching applicability.<br /> <br /> This project will focus on the development of novel stimuli-responsive polymers that will primarily be used for the delivery of drug molecules. In particular, key areas that are required to be addressed in order for the polymer-based drug delivery system to be effective include:<br /> <br /> High loading of freely loaded drug molecules within the polymer carrier.<br /> Polymer functionalisation to facilitate targeting towards specific tumour sites.<br /> The intracellular delivery of microRNA and modified RNA. The polymers used will be biodegradable and produced by controlled polymerisation techniques to generate drug carriers of consistent dimensions.<br /> <br /> Stimuli-responsive elements will be incorporated into the polymer design to maximise the potential application of the polymers produced. Post-polymerisation functionalisation will be done in order to furnish the polymer with elements that enable particular cell targeting and/or polymer tracking in vivo.<br /> <br /> The project is varied in its nature, containing aspects of controlled polymer synthesis, biochemistry (polymer functionalisation) and biomaterials chemistry (the formation of drug delivery vehicles). In addition, a range of analytical techniques will be employed to enhance both student learning and project progression.

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="https://www.leeds.ac.uk/info/130206/applying/91/applying_for_research_degrees">University&#39;s website</a>. Please state clearly in the Planned Course of Study section that you are applying for <strong><em>PHD Chemistry FT</em></strong> and in the research information section&nbsp;that the research degree you wish to be considered for is <em><strong>Novel Polymer Architectures for Controlled Release Applications</strong></em>&nbsp;as well as&nbsp;<a href="https://physicalsciences.leeds.ac.uk/staff/208/dr-paul-thornton">Dr Paul Thornton</a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p style="margin-bottom:11px"><em>As an international research-intensive university, we welcome students from all walks of life and from across the world. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education. Across all Faculties we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community, people who identify as LGBT+ and people with disabilities. Applicants will always be selected based on merit and ability.</em></p> <p class="MsoNoSpacing">Applications will be considered on an ongoing basis. &nbsp;Potential applicants are strongly encouraged to contact the supervisors for an informal discussion before making a formal application. &nbsp;We also advise that you apply at the earliest opportunity as the application and selection process may close early, should we receive a sufficient number of applications or that a suitable candidate is appointed.</p> <p>Please note that you must provide the following documents at the point you submit your application:</p> <ul> <li>Full Transcripts of all degree study or if in final year of study, full transcripts to date</li> <li>Personal Statement outlining your interest in the project</li> <li>CV</li> <li>Funding information including any alternative sources of funding that you are applying for or if you are able to pay your own fees and maintenance</li> </ul> <p>&nbsp;</p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p style="margin-bottom:12px"><strong>Self-Funded or externally sponsored students are welcome to apply.</strong></p> <p><strong>UK&nbsp;</strong>&ndash;&nbsp;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/209-leeds-doctoral-scholarships-2022">Leeds Doctoral Scholarships</a> and <a href="https://phd.leeds.ac.uk/funding/234-leeds-opportunity-research-scholarship-2022">Leeds Opportunity Research Scholarship</a> are available to UK applicants. <a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Non-UK</strong> &ndash;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/48-china-scholarship-council-university-of-leeds-scholarships-2021">China Scholarship Council - University of Leeds Scholarship</a>&nbsp;is available to nationals of China. The&nbsp;<a href="https://phd.leeds.ac.uk/funding/73-leeds-marshall-scholarship">Leeds Marshall Scholarship</a>&nbsp;is available to support US citizens. <a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Important:</strong>&nbsp; Any costs associated with your arrival at the University of Leeds to start your PhD including flights, immigration health surcharge/medical insurance and Visa costs are <strong>not</strong> covered under these studentships.</p> <p>Please refer to the <a href="https://www.ukcisa.org.uk/">UKCISA</a> website for information regarding Fee Status for Non-UK Nationals.</p>

<h2 class="heading">Contact details</h2>

<p>For further information about your application, please contact Doctoral College Admissions: e:&nbsp;<a href="mailto:EMAIL@leeds.ac.uk">m</a><a href="mailto:maps.pgr.admissions@leeds.ac.uk">aps.pgr.admissions@leeds.ac.uk</a></p> <p>For further information about this project, please contact Dr Paul Thornton: e:&nbsp;&nbsp;<a href="mailto:P.D.Thornton@leeds.ac.uk">P.D.Thornton@leeds.ac.uk</a></p>