- Type of research degree
- Application deadline
- Ongoing deadline
- Project start date
- Saturday 1 October 2022
- Country eligibility
- International (open to all nationalities, including the UK)
- Competition funded
- Dr Kevin Critchley and Professor Stephen Evans
- School of Physics and Astronomy
- Research groups/institutes
- Molecular and Nanoscale Physics
Gold nanoparticle exhibit strong optical absorption due to their localised surface plasmon resonance (SPR). All almost all the energy absorbed at the SPR is converted into heat. Controlled delivery of heat could be used to treat cancers and other applications. However, the SPR band of spherical nanoparticles is in the green region of the spectrum and tissue scatter and absorbs light strongly in this region. By controlling the geometry of the gold nanoparticle, it is possible to obtain SPR bands in the near infrared region , i.e. in the so-called ‘biological window.’ However, for these gold nanoparticles to work as photothermal we must develop improved methods to i) target the nanoparticles to specific sites, ii) improve the stability of the gold nanorods under intense laser exposure, and iii) develop the co-delivery of a chemotherapeutic to enhance the treatment effect. In this project you will be synthesizing core-shell nanoparticles (gold silica) and characterising them using spectroscopy and electron microscopy. You will be carefully tunning the properties so that the gold nanorods absorb in the desired range, are all the same size and aspect ratio, and with suitable surface chemistry to allow the surface to mimic a biological membrane. After careful experimental analysis you will test the gold nanorods on cancer cell lines (in well plates) and assess the toxicity and the effect of applying laser light. We will then work on targeting strategies along with methods of delivery of drugs during the application of the laser light. Thus, you will be trained in the synthesis, nano-characterisation, as well as some basic biological assays to test the nanoparticles. You will be working in a newly built, state of the art facility, with access to all of the equipment and training that you need. You will be provided with close supervision to enable you to develop the PhD project.
<p>Formal applications for research degree study should be made online through the <a href="https://www.leeds.ac.uk/research-applying/doc/applying-research-degrees">University's website</a>. Please state clearly in the Planned Course of Study section that you are applying to <em><strong>PHD Physics & Astronomy FT </strong></em>and in the research information section that the research degree you wish to be considered for is <em><strong>Silica Coated Gold Nanorods for Combined Photothermal Treatment</strong></em> as well as <a href="https://eps.leeds.ac.uk/physics/staff/4104/dr-kevin-critchley">Dr Kevin Critchley</a> as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University's minimum English language requirements (below).</p> <p style="margin-bottom:11px"><em>As an international research-intensive university, we welcome students from all walks of life and from across the world. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education. Across all Faculties we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community, people who identify as LGBT+ and people with disabilities. Applicants will always be selected based on merit and ability.</em></p> <p class="MsoNoSpacing">Applications will be considered on an ongoing basis. Potential applicants are strongly encouraged to contact the supervisors for an informal discussion before making a formal application. We also advise that you apply at the earliest opportunity as the application and selection process may close early, should we receive a sufficient number of applications or that a suitable candidate is appointed.</p> <p>Please note that you must provide the following documents at the point you submit your application:</p> <ul> <li>Full Transcripts of all degree study or if in final year of study, full transcripts to date</li> <li>Personal Statement outlining your interest in the project</li> <li>CV</li> <li>Funding information including any alternative sources of funding that you are applying for or if you are able to pay your own fees and maintenance</li> </ul> <p> </p>
Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.
The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.
<p style="margin-bottom:12px"><strong>Self-Funded or externally sponsored students are welcome to apply.</strong></p> <p><strong>UK</strong> – The <a href="https://phd.leeds.ac.uk/funding/209-leeds-doctoral-scholarships-2022">Leeds Doctoral Scholarships</a> and <a href="https://phd.leeds.ac.uk/funding/234-leeds-opportunity-research-scholarship-2022">Leeds Opportunity Research Scholarship</a> are available to UK applicants. The <a href="https://phd.leeds.ac.uk/funding/102-bell-burnell-scholarship-award-awarded-by-the-iop">Bell Burnell Scholarship Award</a> is available to support applicants who are from groups that are currently under-represented in physics (awarded by the IOP) (open from October 2023). <a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Non-UK</strong> – The <a href="https://phd.leeds.ac.uk/funding/102-bell-burnell-scholarship-award-awarded-by-the-iop">Bell Burnell Scholarship Award</a> is available to support applicants who are from groups that are currently under-represented in physics (awarded by the IOP). The <a href="https://phd.leeds.ac.uk/funding/48-china-scholarship-council-university-of-leeds-scholarships-2021">China Scholarship Council - University of Leeds Scholarship</a> is available to nationals of China (open from October 2023). The <a href="https://phd.leeds.ac.uk/funding/73-leeds-marshall-scholarship">Leeds Marshall Scholarship</a> is available to support US citizens. <a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Important:</strong> Any costs associated with your arrival at the University of Leeds to start your PhD including flights, immigration health surcharge/medical insurance and Visa costs are <strong>not </strong>covered under this studentship.</p> <p>Please refer to the <a href="https://www.ukcisa.org.uk/">UKCISA</a> website for information regarding Fee Status for Non-UK Nationals.</p>
<p>For further information about this project, please contact Dr Kevin Critchley<br /> e: <a href="mailto:EMAIL@leeds.ac.uk">email@example.com</a></p> <p>For further information about your application, please contact Doctoral College Admissions<br /> e: <a href="mailto:firstname.lastname@example.org">email@example.com</a></p>
<h3 class="heading heading--sm">Linked research areas</h3>