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Functionalised amino-acid analogues for chemical proteomics

PGR-P-116

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Key facts

Type of research degree
PhD
Application deadline
Ongoing deadline
Country eligibility
International (open to all nationalities, including the UK)
Funding
Competition funded
Supervisors
Dr Michael Webb
Schools
School of Chemistry
<h2 class="heading hide-accessible">Summary</h2>

In this project, you will build on our previous work developing stable analogues of phosphohistidine (Org. Biomol. Chem. (2012)10, 4043), dehydroalanine (Chem Commun. (2015) 51 13470) and triazine-containing analogues of phenylalanine (Chem. Eur. J (2015) 21 14376) to generate new probe molecules for chemical proteomics and chemical biology.<br /> <br /> Dependent upon the particular target these might have applications in the study of protein phosphorylation by chemical proteomics, in general applications for target identification and protein labelling, or enable us to generate highly functionalised proteins in tandem with our sortase-catalysed methdology (Angew. Chem. Int. Ed. (2012) 51 9377)<br /> <br /> The earliest start date for this project is 1 October 2020.

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="https://www.leeds.ac.uk/info/130206/applying/91/applying_for_research_degrees">University&#39;s website</a>. Please state clearly in the Planned Course of Study that you are applying for <em><strong>PHD Chemistry FT </strong></em>and in the research information section&nbsp;that the research degree you wish to be considered for is <em><strong>Functionalised amino-acid analogues for chemical proteomics</strong></em>&nbsp;as well as&nbsp;<a href="https://physicalsciences.leeds.ac.uk/staff/198/dr-michael-webb">Dr Mike Webb</a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p>&nbsp;</p>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<p><strong>Self-Funded or externally sponsored students are welcome to apply.</strong></p> <p><strong>UK&nbsp;</strong>&ndash;&nbsp;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/209-leeds-doctoral-scholarships-2022">Leeds Doctoral Scholarships</a>,&nbsp;<a href="https://phd.leeds.ac.uk/funding/118-lund-stephenson-clarke-scholarship-2022">Lund Stephenson Clarke</a>, <a href="https://phd.leeds.ac.uk/funding/198-akroyd-and-brown-scholarship-2022">Akroyd &amp; Brown</a>, <a href="https://phd.leeds.ac.uk/funding/199-frank-parkinson-scholarship-2022">Frank Parkinson</a>, <a href="https://phd.leeds.ac.uk/funding/205-henry-ellison-charles-brotherton-research-scholarship-2022">Henry Ellison-Charles Brotherton</a> and <a href="https://phd.leeds.ac.uk/funding/204-boothman-reynolds-and-smithells-scholarship-2022">Boothman, Reynolds &amp; Smithells</a> Scholarships are available to UK applicants. &nbsp;<a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p><strong>Non-UK</strong>&nbsp;&ndash;The&nbsp;<a href="https://phd.leeds.ac.uk/funding/48-china-scholarship-council-university-of-leeds-scholarships-2021">China Scholarship Council - University of Leeds Scholarship</a>&nbsp;is available to nationals of China. The&nbsp;<a href="https://phd.leeds.ac.uk/funding/73-leeds-marshall-scholarship">Leeds Marshall Scholarship</a>&nbsp;is available to support US citizens. &nbsp;<a href="https://phd.leeds.ac.uk/funding/60-alumni-bursary">Alumni Bursary</a> is available to graduates of the University of Leeds.</p> <p>Please refer to the <a href="https://www.ukcisa.org.uk/">UKCISA</a> website for information regarding Fee Status for Non-UK Nationals starting from September/October 2021.</p>

<h2 class="heading">Contact details</h2>

<p>For further information regarding your application, please contact Doctoral College Admissions by&nbsp;email: <a href="mailto:maps.pgr.admissions@leeds.ac.uk">maps.pgr.admissions</a><a href="mailto:EMAIL@leeds.ac.uk">@leeds.ac.uk</a>, or by telephone: +44 (0)113 343 5057.</p> <p>For further information regarding the project, please contact Dr Mike Webb by email:&nbsp;&nbsp;<a href="mailto:M.E.Webb@leeds.ac.uk">M.E.Webb@leeds.ac.uk</a></p>