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Electrochemical Flow Processes for Ni-Catalysed Coupling Reactions

PGR-P-1141

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Key facts

Type of research degree
PhD
Application deadline
Friday 29 July 2022
Project start date
Monday 3 October 2022
Country eligibility
UK only
Funding
Competition funded
Source of funding
Research council
Supervisors
Dr Bao Nguyen and Dr Charlotte Willans
Additional supervisors
Nik Kapur
Schools
School of Chemistry
<h2 class="heading hide-accessible">Summary</h2>

Reductive cross-coupling/cross-electrophile coupling reactions are powerful synthetic tools which have gained significant attention with the development of Ni-catalysed processes. Many of these happens through single electron transfers (SETs) and radical intermediates, which enable access to different reactivity to those of traditional Pd-catalysed coupling reactions, e.g. coupling with sp3 partners with retention of stereochemistry. Their main drawback, which restricts scaled-up processes, is the need for stoichiometric reductant, e.g. Zn and Mn, and subsequent problems associated with cost and waste. <br /> <br /> Electrochemical methods present a possible solution to this problem. The reductant with finely tuned redox potential may be electrochemical recycled in situ, changing its role to a redox mediator. Some early successes with organic reductants have been reported, but mechanistic understanding and development in this area has yet to be taken up by the wider community<br /> <br /> In this joint project with AstraZeneca, we aim to develop electrochemical flow processes to enable Ni-catalysed reductive coupling reactions and to generate the required mechanistic understanding for their further development. Flow electrochemical syntheses have the advantages of low over-potential, less side products and higher Faradaic efficiency. The successful flow reactions will be pivotal in the adoption of Ni-catalysed reactions into industrial processes.<br /> <br /> The student will receive training on catalysis, electrochemistry, organometallic chemistry, flow chemistry and reaction optimisation. You DO NOT need to have these skills now, only the willingness to learn and develop them. In addition, the student will benefit from working in the highly interdisciplinary research environment and monthly seminar program in the iPRD (https://iprd.leeds.ac.uk). Opportunities to present work and to network will be provided through the iPRD industrial club meetings, AstraZeneca CASE events and other relevant conferences/meetings.

<h2 class="heading">How to apply</h2>

<p>Formal applications for research degree study should be made online through the&nbsp;<a href="https://www.leeds.ac.uk/research-applying/doc/applying-research-degrees">University&#39;s website</a>. Please state clearly in the Planned Course of Study section that you are applying for <em><strong>PHD Chemistry FT</strong></em> and in the research information section&nbsp;that the research degree you wish to be considered for is <em><strong>Ni-catalysed coupling reactions with electrochemistry in flow</strong></em>&nbsp;as well as&nbsp;<a href="https://eps.leeds.ac.uk/chemistry/staff/4205/dr-bao-nguyen">Dr Bao Nguyen</a>&nbsp;as your proposed supervisor.</p> <p>If English is not your first language, you must provide evidence that you meet the University&#39;s minimum English language requirements (below).</p> <p class="MsoNoSpacing"><strong>Applications will be considered on an ongoing basis. &nbsp;Potential applicants are strongly encouraged to contact the supervisors for an informal discussion before making a formal application. &nbsp;We also advise that you apply at the earliest opportunity as the application and selection process may close early, should we receive a sufficient number of applications or that a suitable candidate is appointed.</strong></p> <p><strong>Please note that you must provide the following documents in support of your application by the closing date of 29 July 2022:</strong></p> <ul> <li><strong>Full Transcripts of all degree study or if in final year of study, full transcripts to date</strong></li> <li><strong>Personal Statement outlining your interest in the project</strong></li> <li><strong>CV</strong></li> </ul>

<h2 class="heading heading--sm">Entry requirements</h2>

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

<h2 class="heading heading--sm">English language requirements</h2>

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.

<h2 class="heading">Funding on offer</h2>

<div class="cms"> <p class="MsoNoSpacing">A highly competitive EPSRC CASE Competition Studentship in partnership with AstraZeneca, consisting of the award of fees with a maintenance grant of &pound;16,062 for session 2022/23 for 3.5 years with an additional Top-Up of &pound;3,000 per year.&nbsp;&nbsp;This&nbsp;will include the opportunity to spend a 3 month placement at AstraZeneca.<br /> <br /> This opportunity is open to UK applicants only. All candidates will be placed into the EPSRC CASE Competition Studentship Award Competition and selection is based on academic merit.<br /> <br /> Please refer to the&nbsp;<a href="https://www.ukcisa.org.uk/">UKCISA</a>&nbsp;website for&nbsp;information regarding Fee Status for Non-UK Nationals starting from September/October 2021.</p> </div>

<h2 class="heading">Contact details</h2>

<p>For further information about this project, please contact Dr Bao Nguyen (e: <a href="mailto:b.nguyen@leeds.ac.uk">b.nguyen@leeds.ac.uk</a>, t: +44 (0)113 343 0109)&nbsp;</p> <p>For further information about your application, please contact &nbsp;Doctoral College Admissions office:&nbsp;<a href="mailto:maps.pgr.admissions@leeds.ac.uk">maps.pgr.admissions@leeds.ac.uk&nbsp;</a></p>


<h3 class="heading heading--sm">Linked funding opportunities</h3>
<h3 class="heading heading--sm">Linked research areas</h3>